Biomechanics

The vision for Biomechanics research at NUI Galway is that of a dynamically evolving world-class research activity, focused on both fundamental and applied research and where the principals of engineering mechanics, and biology, are combined to generate discovery and understanding , and to solve problems, at the interfaces between engineering, biology and clinical practice. Biomechanics research is, therefore, fundamentally multi-disciplinary, involving strong interactions between engineers, life scientists and clinicians. Biomechanics research is particularly relevant in th context of th development of the medical technology industry because it focuses on problems  that are at the very heart of medical device design, and analysis, development and manufacturing. This overall research thrust is wholly consistent with NUI Galway's overall vision to be an internationally recognised centre of excellence in biomedical science and engineering.  
People
Biomechanics Cluster PIs:
 
Professor Peter McHugh, Professor of Biomedical Engineering, Biomechanics Cluster Leader
Dr. Nathan Quinlan, Senior Lecturer in Mechanical Engineering
Dr. Mark Bruzzi, Lecturer in Mechanical Engineering
Dr. Patrick McGarry, Lecturer in Biomedical Engineering
Dr. Laoise McNamara, SFI Stokes Lecturer in Biomedical Engineering

 
Associated Academic and Research Staff:

Professor Sean Leen, Professor of Mechanical Engineering
Dr. Stefan Lohfeld, Research Fellow
Dr. Pat McDonnell, Postdoctoral Researcher
Dr. Noel Harrison, Postdoctoral Researcher
Mr. Brendan Casey, Research Fellow
Dr. Eoin O'Cearbhaill, Postdoctoral Researcher
Dr. Libor Lobovsky, Postdoctoral Researcher
Dr. Barry O'Brien, Research Fellow
Dr. Alessandro Bellofiore, Postdoctoral Researcher
 
Postgraduate Researchers:
Birmingham, Evelyn
Carrington, Martin
Coghlan, Karen
Conway, Claire
Donnelly, Evin
Dowling, Enda
Feerick, Emer
Ganly, Sandra
Grogan, James
Ilie, Daniel
Kelly, Nicola
McSweeney, James
Mullen, Conleth
Ni Ghriallais, Ríona
Noor, Furgan
O'Mairtin, Eamonn
Ronan, William
Ryan, Enda
Weafer, Paul
 
MSc Students:
Connell, Ian
Dooley, Padraic
Hand, Enda
Sweeney, Rory
Thomas, Cathal


Research Themes

Cardiovascular Biomechanics

Orthopedic Biomechanics

Medical Device Design

 
 
The Biomechanics Research Cluster research activities are focused on:
   
Fundamental in-vitro experimental and computational research into the mechanics, mechano-biology and cellular mechano-transduction of healthy/injured/diseased musculoskeletal and cardiovascular tissue and cells. This includes the development of active multi-scale computational models linking cellular formulations to tissue mechanics.

Fundamental explorations of the multi-scale mechanics of fluid flow in the body and in medical devices, focusing on blood flow and biomolecule (drug, gene) elution and transport, with studies from arterial to cellular regimes using a variety of techniques from in-vitro models to cellular studies to computational investigations.

The interaction between the human biological system and biomedical implants and devices, leading to the development of enhanced analysis and design methodologies for implants and devices.

Applied research, complementing and enabled by the fundamental research, focused on the development of innovative and novel therapeutic implants and devices, surgical procedures and production processes.

The research is enabled by the development and implementation of advanced computational mechanics methods, involving multi-physics at multiple scales, and experimentally through the extensive exploitation of novel bioreactor technology.
Publications
McNamara LM, Majeska RJ, Weinbaum S, Friedrich V, Schaffler MB, Attachment of osteocyte cell processes to the bone matrix, Anatomical Record, in press (2009).
 
Wang Y, McNamara LM, Mitchell B. Schaffler, Weinbaum S, Strain amplification and integrin based signalling in osteocytes, Journal of Musculoskeletal and Neuronal Interactions 8(4):332-334 (2008).

B.M. Mulvihill, McNamara LM, Prendergast PJ, Loss of trabeculae in osteoporotic cancellous bone by biomechanical means, J R Soc Interface 5(27):1243-53 (2008).

Mullins, L.P., Bruzzi, M.S., And McHugh, P.E., Authors' Response To "Comments
On `Measurement Of The Microstructural Fracture Toughness Of Cortical Bone
Using Indentation Fracture'", Journal Of Biomechanics, 2008. 41(11): P. 2602-2603.
Flaherty, B., McGarry, J.P. and McHugh, P.E., "Mathematical models of cell motility", available on-line Cell Biochemistry and Biophysics, 2007. doi: 10.1007/s12013-007-0045-2, Invited Paper.
 
McNamara LM, Prendergast PJ, Bone remodelling algorithms incorporating both strain and microdamage stimuli, Journal of Biomechanics, J Biomech. 2007; 40(6):1381-91 (2007).

B.M. Mulvihill, McNamara LM, Prendergast PJ, 2007, The effect of patient-specific bone remodeling rates on remodelling/repair in trabecular bone, III International congress on Computational Bioengineering

Punchard, M.A., Stenson-Cox, C., O'Cearbhaill, E., Lyons, E., Gundy, S., Murphy, L., Pandit, A., McHugh, P.E. and Barron V., "Endothelial Cell Response to Biomechanical Forces under Simulated Vascular Loading Conditions", available on-line Journal of Biomechanics, 2007. doi:10.1016/j.jbiomech.2007.03.029

Mullins, L.P., Bruzzi, M.S., And Mchugh, P., Measurement Of The Microstructural Fracture Toughness Of Cortical Bone Using Indentation Fracture, Journal Of Biomechanics, 2007. 40(14): P. 3285-3288.
Thakral, R., Kaar, K., McHugh, P.E., Brennan, W. and Lalor, S., "Weber B lateral malleolar fracture and inter fragmentary screw placement", available on-line EJOST - European Journal of Orthopaedic Surgery and Traumatology, 2007. doi: 10.1007/s00590-007-0225-1

Harewood, F. and McHugh, P.E., "Modelling of size dependent failure in cardiovascular stent struts under tension and bending", available on-line Annals of Biomedical Engineering, 2007. doi:10.1007/s10439-007-9326-6

Barron, V., Brougham, C., Coghlan, K., McLucas, E., O'Mahoney, D., Stenson-Cox, C. and McHugh, P.E., "The effect of physiological cyclic stretch on the cell morphology, cell orientation and protein expression of endothelial cells", available on-line Journal of Materials Science: Materials in Medicine, 2007. doi:10.1007/s10856-007-3125-3

McNamara LM, Lyons CG, Ederveen AH, H. Weinans, Price CJ, Schaffler MB, Prendergast PJ, Strength of cancellous bone trabecular tissue from normal, ovarectomized and drug-treated rats over the course of ageing, BONE 39(2):392?400 (2006).

McNamara LM, Van der Linden JC, Weinans H, and Prendergast PJ, Stress-concentrating effect of resorption lacunae in trabecular bone, Journal of Biomechanics 39(4):734-41 (2006).

Connolley, T., Nash, D., Buffiere, J-Y. and McHugh, P.E., "X-ray micro-tomography of a coronary stent deployed in a model artery", available on-line Medical Engineering and Physics, 2007. doi:10.1016/j.medengphy.2006.10.016

Mullins, L. McGarry, J.P., Bruzzi, M. and McHugh, P.E., "Micromechanical modelling of cortical bone", Computer Methods in Biomechanics and Biomedical Engineering, Vol. 10, No. 3, pp. 159-169, 2007. doi:10.1080/10255840601110802

Ilie, D.E., O'Donnell, B.P., McGarry, J.P. and McHugh, P.E., "Computational Modelling of the Extrusion of an Al-SiC Metal Matrix Composite using Macroscale and Microscale Methods", Journal of Strain Analysis for Engineering Design, Vol. 42, pp. 237-252, 2007. doi:10.1243/03093247JSA232

McDonnell, P., McHugh, P.E. and O'Mahoney, D., "Vertebral Osteoporosis and Trabecular Bone Quality", Annals of Biomedical Engineering, Vol. 35, No. 2, pp. 170-189, 2007. doi:10.1007/s10439-006-9239-9

Donnelly, E.W., Bruzzi, M., Connolley, T. and McHugh, P.E., "Finite element comparison of performance related characteristics of vascular stents", Computer Methods in Biomechanics and Biomedical Engineering, Vol. 10, No. 2, pp. 103-110, 2007. doi:10.1080/10255840601086234
 
Harewood, F. and McHugh, P.E., "Comparison of the Implicit and Explicit Finite Element Methods using Crystal Plasticity", Computational Materials Science, Vol. 39, Issue 2, pp. 481-494, 2007. doi:10.1016/j.commatsci.2006.08.002

Caulfield, B., McHugh, P.E. and Lohfeld, S., "Dependence of mechanical properties of polyamide components on build parameters in the SLS process", Journal of Materials Processing Technology, Vol. 182, pp. 477-488, 2007. doi:10.1016/j.matprotec.2006.09.007

Lohfeld, S., McHugh, P.E., Serban, D., Boyle, D., O'Donnell, G., Peckitt, N., "Engineering assisted surgery: A route for digital design and manufacturing of customized maxillofacial implants", Journal of Materials Processing Technology, Vol. 183, pp. 333-338, 2007. doi:10.1016/j.jmatprotec.2006.10.028
 
Breen, L., McHugh, P.E., McCormack, B.A., Muir, G., Quinlan, N., Heraty, K. and Murphy, B.P., "Development of a novel bioreactor to apply shear stress and tensile strain simultaneously to cell monolayers", Review of Scientific Instruments, Vol. 77, 104301, 2006. doi:10.1063/1.2356857
 
You, X., Connolley, T., McHugh, P.E., Cuddy, H. and Motz, C., "A Combined Experimental and Computational Study of Deformation in Grains of Biomedical Grade 316LVM Stainless Steel", Acta Materialia, Vol. 54, pp. 4825-4840, 2006. doi:10.1016/j.actamat.2006.06.021
 
Bruzzi, M.S. and McHugh, P.E. (2005) "Micromechanical Modelling of the Static Loading of an Al 359-SiC MMC". Accepted for Publication in the ASME Journal of Engineering Materials and Technology.

Connolley, T., McHugh, P. E., Bruzzi, M. "A Review Of Deformation And Fatigue of Metals at Small Size Scales". Accepted for publication in Fatigue & Fracture in Engineering Materials & Structures. Sept. 2005.

Bruzzi, M.S. and McHugh, P.E. (2004) "Predicting the Effects of Overloads on Fatigue Crack Growth in an Al-SiC MMC Using a Computational Model". ASME Journal of Engineering Materials and Technology, 126, No. 2, 172-178.

Bruzzi, M.S and McHugh, P.E. (2004) "Micromechanical Investigation of the Fatigue Crack Growth Behaviour of Al-SiC MMCs". International Journal of Fatigue. 26, No. 8, 795-804.
 
Liam. P. Mullins, Mark. S. Bruzzi, Peter. E. McHugh. (2004) "Micromechanical Finite element modelling of local stress fields in cortical bone". Bioengineering In Ireland Conference 10, Castleconnell, Co. Limerick

Donnelly, E., Connolley, T., Bruzzi, M.S., McHugh, P.E. (2004) "Finite Element Comparison of Performance Related Characteristics of Cardiovascular Stents". 6th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Madrid, Spain.
 
Bruzzi, M.S. and McHugh, P.E. (2003) "Application of Closure Based Fatigue Modelling Methodology to Al-SiC MMCs". International Journal of Fatigue, 25, No. 7, 577-584
 
Bruzzi, M.S. and McHugh, P.E. (2002) "Methodology for modelling the small crack fatigue behaviour of aluminium alloys". International Journal of Fatigue, 24, No. 10, 1071-1078
 
Bruzzi, M.S., McHugh, P.E., O'Rourke, F., Linder, T. (2001) "Micromechanical modelling of the static and cyclic loading of an Al 2124 - SiC MMC". International Journal of Plasticity, 17, No. 4, 565-599. Ed. Khan, A.S., University of Maryland, Baltimore Co., USA.

McHugh, P.E. & Bruzzi, M. (1999). "Some applications of computational modelling in biomedical engineering science". Presented at MDM2, Conference on Medical Device Manufacturing, NUI, Galway, September, 1999
Collaborations
Cluster members are highly active in terms of inter-disciplinary collaborations both internally and externally, and fully realise and exploit the benefits of these collaborations for the development of the biomechanics research activity at NUI Galway and for raising the international research profile of NUI Galway generally. Key research collaborators with whom cluster members are currently interacting or with whom they have recently interacted are listed below (collaborators on multi-partner EU projects for example are not listed for conciseness).

Academic
Prof. Tim O'Brien, Prof. Frank Barry and the REMEDI team, NUI Galway
Dr. Dimitrios Zeugolis, NFB, NUI Galway
Prof. Fergal O'Brien, RCSI, Dublin
Dr. Danny Kelly, TCD, Dublin
Prof. Suzi Jarvis, UCD, Dublin
Prof. David FitzPatrick, UCD, Dublin
Prof. Tim McGloughlin, UL, Limerick
Prof. Noel O'Dowd, UL, Limerick
Dr. Guillaume Parry, Grenoble Institute of Technology, France
Prof. Michael Liebschner, Baylor College of Medicine, Texas, USA
Prof. Kyriacos Athanasiou, UC Davis, CA, USA
Prof. Robert McMeeking, UCSB, CA, USA
Dr. Vikram Deshpande, University of Cambridge, UK
Dr. Philipp Thurner, University of Southampton, UK
Professor Richard Oreffo, University of Southampton, UK
Professor Mitch Schaffler, Mount Sinai School of Medicine, US
 
 
Clinical
Mr. Bill Curtin, Merlin Park Hospital
Dr. Fintan Shannon, Merlin Park Hospital, Galway
Prof. John Laffey, University Hospital Galway
Dr. Jim Crowley, University Hospital Galway
Dr. Gerry O'Sullivan, University Hospital Galway
Dr. Peter McCarthy, University Hospital Galway
Dr. Hannan Mullett, Beaumont Hospital, Dublin
 
 
Industry
Medtronic Vascular, Galway
Boston Scientific, Galway
Aerogen, Galway
Veryan Medical, Galway
Stryker Instruments, Cork
Vysera Biomedical, Galway,
Brivant Ltd., Galway