Our People

Biosketch

Dr. Serrador is a Visiting Professor from the Dept of Neurology, Harvard Medical School where he has focused on regulation of brain blood flow. His research interests included orthostatic intolerance (fainting), vestibular function (balance), spaceflight, sleep, stroke and aging. His work focuses on integrative physiology, examining the role that different systems play in affecting cerebral blood flow.
He received his BA (Psychology) and BSc degree from the University of Waterloo, Waterloo, Ontario, Canada in 1993. He went on to complete a MSc (Kinesiology) also at the University of Waterloo in 1997 before completing his PhD (Kinesiology) at the University of Western Ontario, London, Ontario, Canada in 2000. He is currently the recipient of the SFI E.T.S. Walton Visiting Professor Award in the Electronic and Electrical Engineering Department at NUI Galway where he is collaborating with Prof Ó Laighin to examine the effect of electrical stimulation on muscle blood flow. His is also an instructor in the Dept. of Neurology at Harvard Medical School and a Clinical Research Investigator at Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Dr. Serrador has published 19 peer reviewed articles and 4 reviews and book chapters since completing his doctorate in 2000. He has been cited over 350 times and his work published in Stroke in 2000 is one of the most cited papers of that year. He completed a postdoctoral fellowship from 2000-3 at the Hebrew Rehabilitation Center for Aged, Boston, USA. Since then he has been funded by NASA and the National Institutes of Health to study the effects of vestibular function on cerebral blood flow regulation. Dr. Serrador has supervised a number of undergraduate, graduate and medical fellows. Recently his MSc student won the 2008 Graduate Student Research Award at 19th International Symposium on the Autonomic Nervous System and his medical fellow was awarded the 2008 Neurocritical Care Society Young Investigator Award.
Dr. Serrador is considered a world expert in Doppler measurements of cerebral blood flow and has been recruited by a variety of groups including the NASA Ames Research Center; NASA Johnson Space Center, University of Kentucky, New York Medical College, and Harvard Medical School Pepper Center on Aging to consult on brain blood flow measurement. Dr. Serrador is currently expanding his research to use advanced spectral analysis techniques to better understand physiological signals. In addition he is examining the effects of stochastic noise on physiological signals and how these inputs may improve performance of various systems.
 
   
Research Interests
Dr. Serrador is a Visiting Professor from the Department of Neurology, Harvard Medical School where he has focused on regulation of brain blood flow. His research interests included orthostatic intolerance (fainting), vestibular function (balance), spaceflight, sleep, stroke and aging. His work focuses on integrative physiology, examining the role that different systems play in affecting cerebral blood flow.
Key Publications
Journals

19. Kazuma N*, Serrador JM*, LaRose SL, Moslehi F, Lipsitz LA, Sorond FA. Autoregulation in the Posterior Circulation is altered by the Metabolic State of the Visual Cortex. Stroke, (in press).  * denotes shared first authorship

18. Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. Cardiovascular, Inflammatory, and Metabolic Consequences of Sleep Deprivation. Progress in Cardiovascular Diseases, 2009:51(4) 294-302.

17. Sorond FA, Serrador JM, Jones RN, Shaffer ML, Lipsitz LA. The sit-to-stand technique for the measurement of dynamic cerebral autoregulation. Ultrasound Med Biol. 2009;35(1):21-9.

16. Sorond FA, Shnyer DM, Serrador JM, Milberg WP, Lipsitz LA. Cerebral Blood Flow Regulation During Cognitive Tasks: Effects of Healthy Again. Cortex. 2008;44(2):179-84.

15. Serrador JM, Hughson RL, Kowalchuk JM, Bondar RL, Gelb AW. Cerebral blood flow during orthostasis: role of arterial CO2. Am J Physiol Regul Integr Comp Physiol. 2006;290(4):R1087-93.

14. Lipsitz LA, Iloputaife I, Gagnon M, Kiely DK, Serrador JM. Enhanced vasoreactivity and its response to antihypertensive therapy in hypertensive elderly women. Hypertension. 2006;47(3):377-83.

13. Sorond FA, Khavari R, Serrador JM, Lipsitz LA. Regional cerebral autoregulation during orthostatic stress: age-related differences. J Gerontol A Biol Sci Med Sci. 2005;60(11):1484-7.

12. Serrador JM, Schlegel TT, Black FO, Wood SJ. Cerebral hypoperfusion precedes nausea during centrifugation. Aviat Space Environ Med. 2005;76(2):91-6.

11. Lipsitz LA, Gagnon M, Vyas M, Iloputaife I, Kiely DK, Sorond F, Serrador J, Cheng DM, Babikian V, Cupples LA. Antihypertensive therapy increases cerebral blood flow and carotid distensibility in hypertensive elderly subjects. Hypertension. 2005;45(2):216-21.

10. Serrador JM, Sorond FA, Vyas M, Gagnon M, Iloputaife ID, Lipsitz LA. Cerebral pressure-flow relations in hypertensive elderly humans: transfer gain in different frequency domains. J Appl Physiol. 2005;98(1):151-9.

9. Kimmerly DS, Tutungi E, Wilson TD, Serrador JM, Gelb AW, Hughson RL, Shoemaker JK. Circulating norepinephrine and cerebrovascular control in conscious humans. Clin Physiol Funct Imaging. 2003;23(6):314-9.

8. Wilson TD, Serrador JM, Shoemaker JK. Head position modifies cerebrovascular response to orthostatic stress. Brain Res. 2003;961(2):261-8.

7. Serrador JM, Wood SJ, Picot PA, Stein F, Kassam MS, Bondar RL, Rupert AH, Schlegel TT. Effect of acute exposure to hypergravity (GX vs. GZ) on dynamic cerebral autoregulation. J Appl Physiol. 2001;91(5):1986-94.

6. Houtman S, Serrador JM, Colier WN, Strijbos DW, Shoemaker K, Hopman MT. Changes in cerebral oxygenation and blood flow during LBNP in spinal cord-injured individuals. J Appl Physiol. 2001;91(5):2199-204.

5. Blaber AP, Bondar RL, Moradshahi P, Serrador JM, Hughson RL. Inspiratory CO2 increases orthostatic tolerance during repeated tilt. Aviat Space Environ Med. 2001;72(11):985-91.

4. Serrador JM, Shoemaker JK, Brown TE, Kassam MS, Bondar RL, Schlegel TT. Cerebral vasoconstriction precedes orthostatic intolerance after parabolic flight. Brain Res Bull. 2000;53(1):113-20.

3. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL. MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke. 2000;31(7):1672-8.

2. Serrador JM, Finlayson HC, Hughson RL. Physical activity is a major contributor to the ultra low frequency components of heart rate variability. Heart. 1999;82(6):e9.

1. Serrador JM, Bondar RL, Hughson RL. Ventilatory response to passive head up tilt. Adv Exp Med Biol. 1998;450:133-9.
 
Reviews/Chapters/Editorials

4. Sorond FA, Serrador JM. Cerebral Autoregulation in Stroke. US Neurology, in press.
3. Serrador JM, Milberg WP. Cerebrovascular Hemodynamics and Cerebral Autoregulation in the Aging Brain. In: Cohen RA, 
       editor. Neuropsychology of Cardiovascular Disease. Oxford University Press, in press.
2. Serrador JM, Milberg WP, Lipsitz LA. Cerebral Hemodynamics in the Elderly. In: Paul RH, Cohen RA, Ott BR and Salloway
        S, editors. Vascular Dementia: Cerebrovascular Mechanims and Clinical Management. Humana Press; 2004. p. 75-86.
1. Serrador JM, Wood SJ. Neurohumoral Link Between Nausea and Motion Sickness: A Response. Aviation, Space, and 
        Environmental Medicine. 2005;76(8):805-806.